Parameters Autumn 2023 Demi Issue
نویسندگان
چکیده
منابع مشابه
Topical Reviews Series 6 Issue 4 – Autumn 2009
• Disorders of the enthesis are ripe for further clinical, imaging and translational research ‘Enthesitis’ is the term used to describe inflammation at tendon, ligament or joint capsule insertions. It thus applies to disease associated with the spondyloarthritides (SpA) including ankylosing spondylitis, psoriatic arthritis, reactive arthritis and undifferentiated SpA. The term ‘enthesopathy’, h...
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In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...
متن کاملdemi Package Vignette
3 Differential expression analysis 4 3.1 Defining data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.2 Clustering of probes evaluation of probe expression profiles . . . . . . . . . . . . 5 3.3 Differential expression analysis from probes to annotation . . . . . . . . . . . . . 6 3.4 Functional annotation analysis . . . . . . . . . . . . . . . . . . . . . . ....
متن کاملDmd059675 2023..2032
Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...
متن کاملDev104240 2014..2023
Tissue homeostasis is maintained by adult stem cells, which selfrenewand give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate ...
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ژورنال
عنوان ژورنال: Parameters
سال: 2023
ISSN: ['0031-1723']
DOI: https://doi.org/10.55540/0031-1723.3230